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Age with age, tissue fibroblasts significantly prolonged the cell cycle, resulting in delayed healing.
A wide range of subcutaneous fat in adipose tissue easy to form die-cavity and wound hematoma, impeding the release of oxygen to the wound, provides a focus for infection. Adipose tissue is relatively avascular, wound insufficient blood supply, it increases the risk of infection.
Malnutrition malnutrition can significantly delay wound healing. Wasting in patients with recent weight loss of greater than 10% will be a marked increase in wound complications. Collagen metabolism are part of the body protein metabolism, malnutrition, negative nitrogen balance caused by the body will inevitably affect the collagen synthesis, so as soon as possible after the patients received exogenous protein.
Vitamin vitamin A in wound healing phase of inflammation has a positive effect. It adopted the role of lysosomal membrane enhance inflammatory response, increase access to wound monocytes, macrophages and lymphocytes and other inflammatory cells, and regulation of collagenase activity, contribute to collagen synthesis in mature, epithelial regeneration and angiogenesis , but also to improve the surgical trauma caused by the immune function suppression.
Thus vitamin A can improve wound healing, in particular, can be corrected by hormone-induced delay in healing. It was pointed out that local use of vitamin A can only enhance the process of epithelial wound, and systemic use of vitamin A can affect the collagen calm. Excessive vitamin A will lysosome membrane instability, increasing the severity of inflammatory response. Vitamin C are neutrophils produce peroxide to kill bacteria necessary, and are conducive to macrophage phagocytosis and migration, at the same time as the hydroxylation of proline and lysine auxiliary factor, can promote collagen synthesis and cross-linking, enhance wound strength. Trauma is often accompanied by increased consumption of vitamin C, reduce the level of plasma of severe trauma who should be to add a large number of vitamin C. The role of vitamin E is not clear.
Its antioxidant properties can protect the wound from the release of granulocyte oxygen free radical damage, it is clear that when large doses delayed healing (vitamin A can inhibit this role), so vitamin E can be used for amendments to scar formation, and its side effects than hormone side effects. Vitamin B1 is conducive to enhance lysine hydroxylase activity, and promote cross-linked collagen peptides enhance wound strength.
Zinc are essential trace elements in the human body, especially as DNA polymerase and RNA polymerase of coenzyme components, and cell division and protein synthesis are closely related. Zinc deficiencies in the body of post-traumatic fibroblasts decrease in collagen synthesis decreased and protein metabolism in non-performing. Zinc after injury can improve this situation, but also to ease inflammation, this may be through the maintenance of thymic function and T cell response, enhance immune function and reduce inflammatory cell infiltration and an indirect role. Zinc as the Su-taste elements, one element, zinc helps to increase appetite, improve nutritional status.
Zinc is also involved in a number of enzyme digestion and absorption on the synthesis and activation, it can increase the body’s zinc intake of nutrients bioavailability. In addition to other than zinc, copper, iron, manganese, iodine and other trace elements also involved in the process of protein synthesis body. Therefore, in patients with reduced food intake, inadequate intake of trace elements of the case, should not such as to add a timely manner appropriate for their trace element preparations, often will affect the speed of wound healing and patient rehabilitation.
Because of the human body’s physiological needs for trace elements in very small changes in the scope of clinical applications to be added to its appropriate dosage. Therefore, trauma surgeons need to attach importance to the observation of trace elements before and after surgery.
Diabetes patients with high blood sugar inhibition of neutrophil function, wound the weak inflammatory response, which directly led to fibroblast growth and collagen synthesis reduction. Such patients with skin wounds dermal papilla layer of hyaluronic acid than the normal decrease in the collagenase content was significantly increased, this phenomenon may affect the healing tensile strength and collagen organization of the gathering.
In addition, patients with diabetes due to vascular pathological changes, making Lower blood perfusion, tissue hypoxia, wound infection danger.
Uremic patients is not easy to heal wounds, and its main mechanism may lie in systemic malnutrition, wounds and wound hypovolemia insufficient oxygen supply. Experiments have shown that hyperlipidemia so wound fibroblast collagen synthesis function decreased. The reason could be that:
① fibroblast lipid droplets in the cytoplasm must occupy space, and can not be used directly to affect the normal function of the endoplasmic reticulum.
② When the macrophage phagocytosis of lipid into foam cells, the secretion of fibroblast growth factor contributed to the dysfunction, indirectly affect the collagen synthesis.
Anti-inflammatory drugs on healing adversely, it may be inhibiting the healing process of inflammatory period, but its impact on wound was strictly dose-dependent, usually not the role of dose in general. Chemotherapeutic drugs to reduce the bone marrow cells so that the number of inflammatory cells and platelets decreased growth factor-related deficiencies, delayed the normal wound healing.
Antineoplastic agents also inhibit metabolism, so that reduces the diameter of collagen, wound collagen accumulation reduced, lower tensile strength. Exogenous adrenocorticotropic hormone impede wound healing, mainly cortisone lysosome membrane stability and prevent proteolytic enzyme and other pro-inflammatory reactive substances released, inhibiting the early wound inflammatory response. This role to 3 d after injury with a particular administration.
High-dose steroids may also inhibit proline hydroxylase and lysine hydroxylase activity, increased collagenase activity, and inhibited macrophage function, TGF2β secretion decreased, affecting wound healing.
Smokers of its blood circulation increase in carbon monoxide, carbon monoxide combines with hemoglobin to reduce the release of oxygen. In addition, the nicotine would peripheral vascular contraction, long-term smokers may be peripheral vascular disease, the impact of wound healing.
Radiotherapy will damage the small blood vessels, resulting in obliterative endarteritis and direct injury of various types of cells. Trauma early high-dose irradiation can significantly delay wound healing strength increased after 2 weeks after radiotherapy has been relatively safe.
Some other non-injury factors such as social factors, occupational instability, as well as the spirit of emotional anxiety and so on, through neuroendocrine-immune function, will also affect the wound healing process.
Wound infection caused by abnormalities, mainly of collagen metabolic disorder. Infected areas neutrophils after phagocytosis of bacteria, the release of protease and oxygen free radicals can damage organizations, so that dissolved more than collagen deposition, causing delayed wound healing. When the existence of infection, bacteria and inflammatory cells, an increase of oxygen and other nutrients consumption, impaired fibroblast metabolism, but also a lot of infected exudate, and increased local tension of the wound.
Time opened a hematoma can form a die cavity, increasing the chances of infection, and hematomas have a toxic effect will be to promote necrosis. Good local blood circulation, both to ensure that the necessary nutrition and oxygen, but also conducive to necrosis of the material to absorb, transport, control of local infection. Blood supply by the anatomical location of incision site, their disease (especially atherosclerosis), and suture tension and so on.
Jonsson on 33 postoperative patients detected, wound collagen content and wound strength, and wound tissue oxygen tension and tissue perfusion was a positive correlation. Must be pointed out that should not affect the local oxygen and wound healing, and only blood pressure can help improve wound healing. In addition, the fixed position for the bones, nerves, blood vessels, tendon repair is very important.
Nearby joints too early activities are easily wound in the process of increasing the inflammatory exudative reaction, local swelling exacerbate the impact of the blood supply, and new granulation tissue is very fragile, easily lead to injury involves bleeding, the impact of fibroblast differentiation and the formation of scar tissue.
Ways to promote wound healing
Minimize the impact on wound healing factors, certain amino acids such as hydroxyproline, methionine, arginine, etc. in the wound healing process play the role of facilitator. Arginine its mechanisms to promote wound healing may be through regulation of T cell function affected fibroblast activity. Postoperative given amino acid-rich food, or directly to the collagen-rich pig, or pig’s feet for a class of food, are very helpful.
Because of cell membrane lipids and inflammatory mediators as the basis of total parenteral nutrition patients, more than 1 ~ 2 weeks should be considered for essential fatty acids containing the emulsion. Hyperfunction on metabolism, long-term fasting sick Special attention should also be added vitamins and trace elements. Vitamin A are patients should pay attention to nutrients. After a certain period of time the body has more or less a low zinc status, food and animal skin have a high amount of zinc to pigskin or feet as a supplement of glycine, proline has also been much zinc .
Clinical surgery abroad has generally been for the trauma and burn patients to add trace elements, but the practical application, the main body to consider the nutritional status of patients and disorders of the special requirements of nutrients.
The use of laser technology
Spectrum red and near infra-red on the skin penetration depth of the largest and therefore more use of clinical wound He2Ne laser irradiation. He2Ne laser irradiation on proliferation of fibroblasts had no effect on cell division, it has to stimulate fibroblast collagen synthesis to type Ⅰ, Ⅲ procollagen gene expression to enhance the role. The role of laser irradiation is closely related with the radiation dose. Under normal circumstances, with a small dose to stimulate the excitatory effect, while high-dose inhibition.
Actual use should be based on age, location and nature of lesions, skin color and laser wavelength and other factors to select the radiation dose  It also found that the early traumatic wound higher laser reflectivity gradually declined, while the healing rate of the late reflex rising trend. This prompted us to be in accordance with the reflectivity changes over time in drawing up the corresponding radiation dose curve, so that each absorption of laser energy to achieve the best therapeutic dose, thus speeding up wound healing, improve efficacy.
Application of genetic engineering
Gene recombination technology in recent years the rapid development of substantial preparation of the body content of protein or peptide little technology has been sophisticated. Synthetic collagenase now have a wide range of commercialization of products, although their roles will be affected by local micro-environmental impact, but the clinical application of collagenase can accelerate debridement and wound healing and reduce scar formation, especially for complex burns and refractory chronic ulcers, enzymatic debridement with surgical debridement and sometimes more than unique.
With the genetic engineering technology development and applications, the majority of known growth factors have been genetically engineered products. Epidermal growth factor (EGF) in some European countries have been approved as a topical treatment of ocular wound medication.
The main questions now are how to use the growth factor and its security issues. Growth factor because of faster degradation in vivo, the use of drug delivery should be considered on time, etc. Additional questions. Some external growth factor carriers and formulations such as gel, lotion and a bandage being investigated.
As for security issues, the existing studies have shown that at a steady increase in the occurrence of tumor growth factors or receptors are important, but the temporary supply of exogenous endothelial growth factor and should not happen to achieve the above conditions. But on this issue in-depth study will be growth factor drugs widely used to provide security guarantees.
The use of bio-engineering materials
The current Canadian and European countries at the edge of neatly wound on the use of tissue adhesive, or selective adhesive wound simultaneously with the growth factor used increasingly common. Adhesives commonly used fibrin glue and there is cyanide-acrylate. For large-area burns and other trauma and severe trauma, application of skin substitutes to promote epithelial regeneration and re-epithelization has important significance. Skin substitute materials can be divided into natural materials and artificial materials. Studies have shown that cultured autologous or allogeneic graft on Pipi degree burn in Ⅲ after because of the lack of dermal basement, easy to tend to the wound scarring.
For the purpose of producing a better wound healing, can provide the dermis contains collagen analogues transplanted into patients. Such artificial dermis with biodegradable properties, the body will not be retained long-term rejection and loss, wound stromal cells can grow into the artificial dermis, and connective tissue gradually formed. There is a more cost-physiological Synthesis Materials are posed by the bilayer membrane surface for the silicone rubber, inner layer for a combination of collagen peptides nylon. Inner layer of collagen peptide collagen wound happened with chemical combination, but once the wound infection is becoming less binding. In addition, from the dried small shrimps, crab, turtle shells to extract the chitin, but also can increase the accumulation of fibroblasts and collagen synthesis. Wound repair materials are the future trend of development, development that can release growth factors to stimulate healing drugs or dressings, patient autologous skin and epithelial cells has been to maximize utilization.
Chinese medicine’s unique role in wound healing in Chinese medicine is very rich, with a long history, the accumulation of an extremely valuable clinical experience, the formation of a unique theoretical system. Differential Treatment of Chinese medicine, improve the cure rate of wound repair and function of intact rate. Chinese medicine for the treatment of wound healing, to implement the “combination of inside and outside”, “static and dynamic binding,” “both bones,” “physician-patient cooperation” principle, and stressed that there is blood injury, so huoxuehuayu wound healing are used by law must .
At present, the relevant reports very many recipes, but have to further verify. Through the observation of cell structure and found that external application of Chinese medicine can enhance local wound microvascular permeability, which is an increase in new capillaries, endothelial cell thinning, fold increase in the relevant. This phenomenon prompted for external use of Chinese medicine “blood” is a prerequisite for wound healing, “long cuddle septic flesh” is the process of wound healing and results.
Co-infection of wounds, the traditional Chinese medicine has a go-rot Shengji law experience and the precise effect, but with the social progress, the development of international exchanges, the development does not contain heavy metals has become a development trend of Chinese medicine, is causing widespread attention. Over the past decade of single drugs, compound drugs in vitro in vivo pharmacology, also conducted a comprehensive evaluation studies.
Summarized the results from the main as follows: acidification of the wound, nutrition wound, immune regulation, and promote blood circulation, sub role, bactericidal antimicrobial, forming a protective layer to protect the wound, as well as analgesics, such as. In short, the traditional Chinese medicine on the wound healing study still need systematic, and should follow the characteristics of Chinese medicine to Chinese medicine theory, developed in line with international standards and requirements for high-performance drugs, this may be the future focus of the research in the field.Tags: blood circulation, protein metabolism, trace elements, traditional chinese medicine
Constipation is not a serious illness, but it suffers. Solution not suffering from needless to say,shit accumulation in the intestine, the continuous gas, toxin, causing gastrointestinal disorders, endocrine disorders, poor sleep, mental tension and so on, these “legacy” is even more distressing. Some people say that I kept eating the fruit, with oil at the fire are rarely touched, why would it constipation? It was also noted that traditional Chinese medicine in the food carrot, celery and I eat every day, why do the same cannot take away constipation? For this reason, many experts suggest that in the constipation diet, the U.S. really a lot of errors.
Misunderstanding 1: Eat more carrots to purge. “In fact, this is a very common constipation diet of the misunderstanding.” China Academy of Traditional Chinese Medicine Dongzhimen Hospital Professor gingerLiang Tudor pointed out that constipation is divided into many types, such as the heat caused by hot lit Peru, spleen and kidney deficiency and body fluid loss virtual virtual secret, such as lead. In middle-aged and old, the true secret very large percentage. Simple point of saying that the lack of gastrointestinal motility. “White radish Xiaoshi has the role of gas, flatulence and constipation, eat really useful. But for middle-aged and elderly, the gas would have on the shortage of gas and then diarrhea diarrhea, constipation even heavier.” Ginger named Murdoch.
Misunderstanding 2: dietary fiber should eat more. “Dietary fiber can indeed alleviate constipation, but it can also lead to flatulence and abdominal pain, gastrointestinal function many poor food but will result in stimulating the gastrointestinal tract.” Beijing Chaoyang hospital dietitian nutrition Song told reporters. “Also not all rich in dietary fiber have a laxative effect of food, such as yam, it is of partial warm, eat more instead of aggravating constipation.” Ginger many added.Tags: gastrointestinal disorders, gastrointestinal function, gastrointestinal tract, mental tension, traditional chinese medicine
Traditional Chinese medicine for lung Jiao dirty, cold and heat intolerance, the most hi-ching gas fumigation, the most evil force dry air inflammation.
And cigarettes as drug hot dry evil, long-term smoking, are most vulnerable to lung injury, heat attacks the lungs, caused by lung fluid loss Xuan Division, lung canopy, fire poison on Kaoru, Alexa fluid into phlegm, and ultimately caused by a variety of symptoms. Regarding the treatment for pulmonary physiological function and drug pathological features, and more to Qingre Huatan, Yangyin Moistening Lung for law.
Here, we introduce a number of therapeutic side, with a view to pass the “therapeutic” to the prevention of tobacco-induced diseases and reduce the harm of smoking.
1. Bulbus fritilariae Sydney lung soup
Check lung 120 grams, wash, cut pieces, opening up the water boiled five minutes, then wash in cold water, dry the water. Fritillaria will wash smashed nine grams; Sydney skins washed heart untiringly and pears, pear skin even small pieces of meat. Add the boiling water pot all materials, text cook two hours, after seasoning with the volume of drinking.Tags: harm of smoking, pathological features, physiological function, sydney check, traditional chinese medicine
Do you know the mouth saliva saliva what role it? Saliva in traditional Chinese medicine called “gold saliva”. Modern medicine has been that the saliva in the mouth just a digestive juice, and its role is to help digestion and mixing, moist food.
Saliva in the eyes of everyone, commonly known as “water”, usually appears not very eyes, in fact, the role of oral health is very important.
Saliva summed up the effectiveness of the following points:
Mouth saliva on the food can be contained in the decomposition of starch, which generated globulin on bacteria, viruses are resistant, can protect the teeth, gums, oral mucosa.
Mucin mouth oral mucosa can be lubricated to prevent the teeth chewing wear, when to eat will also help swallowing.
3.Oral pH buffer:
Saliva in the mouth play pH buffer, with the PH value of between 5-7 changes in the regulation of dental mineralization ability to be effective in preventing dental caries.
4.Cleaning the mouth:
Saliva could be the teeth, oral cleansing efficacy have to reduce the multiplication of bacteria, has played the role of oral health.
Saliva contains a large number of proteins, amino acids, vitamins and other nutrients, can strengthen the facial muscles, blood vessels, nerves, and has anti-aging effect.
In addition, there are antidotes saliva, bleeding, and many other anti-inflammatory effects.
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In fact, teeth whitening methods there are many, but the key to whether the use of methods of traditional Chinese medicine to know that “symptomatic medication,” the only effective method of treating diseases. Well, today we introduce the following different types of dental teeth whitening method.
Dental beauty is essentially a removal of tooth enamel and the stain and pigment quality procedures. According to the depth of the color of teeth, the formation of reasons, to adopt a different approach to whitening.
Such kind of normal tooth surface stain, as long as the pollutants removed, will be able to restore the teeth white, scaling can be washed about six months time. Another optional appliances usually teeth whitening toothpaste function, pay attention to less smoking, cutting colored drinks.
2.Drug rinse method
Apply mainly to mild pigment teeth, enamel hypoplasia, due to age of the tooth enamel to changes in color yellow. Heavier tooth of color, yellow die, such as less effective, because only the surface of white, non-durable. At present, hydrogen peroxide bleaching, such as integrated decolorization, the general price of such products abroad about half expensive than domestic.
Specific approach is in accordance with your doctor first to make a payment of conodonts Tray, and then every night before going to bed to bleach solvent point into the custom-made trays, the wear in the teeth to remove stains up gradually to reach the bleaching effect. Drug decolorization risk small, quick, it takes about three weeks treatment.
Clinical practice has proved that bleach pulp on the gums and no damage, as long as the dentist under the guidance of bleaching is safe, convenient and effective.
Veneer is stained teeth surface similar to a normal tooth paste layer of colored material, to cover the color of teeth. Now more widely used is the resin materials, but the resin itself translucent, so the effect of moderate colored teeth, and a serious tooth such as less than the best ideals.
Photosensitive surface can be maintained for several years, but easy to fall off, easy to change, causing gingival swelling, bleeding and other shortcomings. But because of their low cost, simple operation, the domestic is still used. In addition, the porcelain veneer is currently home to promote its advantages in order to fully cover pigment, sturdiness and durability, lifelike appearance.
If you want to smile more brilliant, go try. Porcelain is the best way to maintain the longest time, you can use for decades. Mainly applicable to moderate and severe tooth, yellow die, enamel hypoplasia, teeth have cracks, defects, holes in the case of serious.
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